SWORBHP is currently involved in the following research studies that are in the development phase, data collection phase, data analysis phase or being prepared for dissemination. Listed are the Principal Investigators along with any Co-investigators that are affiliated with SWORBHP.
In The Works
This study’s objective is to determine the clinical outcome of ROS patients that scored in the “high risk” and “medium risk” categories of the NEWS. The primary objective is to evaluate the outcomes of patients for which the NEWS has been validated; the risk of ICU admission and mortality at 48hrs and 30 days. Patients will be stratified into those who refused and accepted transport. For both groups the primary outcome is ICU admission or mortality at 48 hours and 30 days
- To determine the length of time that patients with sepsis wait for assessment in the emergency department at LHSC after arrival via EMS.
- To determine the length of time that patients with sepsis wait for treatment with antibiotics in the emergency department at LHSC after arrival via EMS.
A Pragmatic Strategy Empowering Paramedics to Assess Low-Risk Trauma Patients with the Canadian C-Spine Rule (CCR) and Selectively Transport them Without Immobilization - (C. Vaillancourt, M. Davis, P. Bradford)
The investigators will evaluate the possibility and benefits of allowing paramedics to use the CCR in the field in 12 communities from across Ontario. The investigators will also measure the impact on the ED, and how much money could be saved if more paramedics were allowed to use the CCR. The investigators will also assess if sex, age, language barriers, or living far from the hospital (long transport time) will affect the outcomes of the study- dissemination preparation
Multi-centre randomized control trial examining if double sequential defibrillation or vector change defibrillation results in a significant improvement in neurologically intact survival in patients with refractory VF – data collection phase
CanROC Epinephrine Dose: Optimal versus Standard Evaluation Trial - EpiDOSE - (S. Lin, M. Davis, P. Bradford)
A prospective, multi-centre, single-blinded, randomized controlled trial to determine if treatment with a low cumulative dose of epinephrine compared to treatment with a standard cumulative dose of epinephrine during resuscitation in adult out-of-hospital cardiac arrest patients with ventricular fibrillation or pulseless ventricular tachycardia improve survival to hospital discharge – development phase
The purpose of this study is to evaluate the performance of the Canadian EMS Syncope Risk Score (CESRS) for use by paramedics in the prehospital setting to accurately predict the risk of significant adverse event occurring within 30 days for patients with syncope – development phase
Pediatric Out-of-Hospital Cardiac Arrest Resuscitation: Evaluation of IM Epinephrine - The PRIME Trial - (J. Tijssen, M. Davis)
The PRIME Trial is a pragmatic, two-arm, open-label, prospective stepped-wedge cluster randomized control trial (SW-CRCT). The purpose of this trial is to determine if IM epinephrine, added to standard of care, will improve time to ROSC (primary outcome) compared to standard of care alone – development phase
Canadian Resuscitation Outcomes Consortium - CanROC/OPALS - (C. Vaillancourt, M. Davis, P. Bradford)
The Ontario Prehospital Advanced Life Support Study (OPALS) is a long-standing collaboration among several Ontario communities. Since 1994 this research collaboration, lead out of the Ottawa Hospital Research Institute has been collecting key information on out-of-hospital cardiac arrest and traumatic injury – data collection, analysis, dissemination phases
The overall objective of the project is to develop an accurate, comprehensive, population based database of sudden cardiac arrest patients to measure the true burden of SCA within the Ottawa-OPALS Network of seven Ontario Communities (Ottawa, London, Windsor, Niagara, Thunder Bay and Kingston) – data collection, analysis, dissemination phases