Date Published

October 4, 2022

Updated For

ALS PCS Version ALS PCS Version 5.2


Should Ibuprofen be withheld for patients suffering possible Crohns, colitis and IBS flare ups?


Ibuprofen can be withheld in any patient that tells you they have a condition wherein they should not receive NSAID. However, it is reasonable to administer Ibuprofen to a patient with Inflammatory Bowel Disease (Chrohns, Ulcerative Colitis) or Irritable Bowel Syndrome (IBS), who does not tell you they should abstain from NSAIDs. It is not a Contraindication per the Analgesia Medical Directive. There is some published information that NSAID use may cause a flares in these conditions. However, a recent meta-analysis shows the data is conflicting and the answer is not clear. Therefore, a single dose of Ibuprofen is unlikely to cause a flare and should not be routinely withheld.

Kefalakes, H., Stylianides, T.J., Amanakis, G. et al. Exacerbation of inflammatory bowel diseases associated with the use of nonsteroidal anti-inflammatory drugs: myth or reality?. Eur J Clin Pharmacol 65, 963€“970 (2009).



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