Question: In regards to gravol. Pregnancy is not a contradiction but after doing research most medical journals state the following: because the studies in humans cannot rule out the possibility of harm, Dimenhydrinate should be used during pregnancy only if clearly needed. What are your thoughts?

 Great question, gravol is not routinely used in pregnancy for the reasons you have pointed out, and in fact most drugs are avoided if possible. One of the best and fast resources is MOTHERISK at sick kids.

www.motherisk.org. They have an algorithm where they speak of Diclectin orally, IV Gravol dimenhydrinate, and IV fluids if there is clinical dehydration.

Prospective research on these medications is difficult to do in pregnancy, as there are ethical challenges getting studies approved. That being said hundreds of thousands of women in North America have used Gravol in pregnancy without issue.

The challenge is that electrolyte depletion, and dehydration could potentially lead to stress on the pregnancy, and this may out way any fears or concerns with the lack of large multi center prospective research on any of the medications.

http://www.motherisk.org/documents/Revised_NVP_Algorithm.pdf

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