When utilizing the analgesia Medical Directive: Remember, “Whenever possible, consider co-administration of acetaminophen and ibuprofen.” The reason being that both act in different ways to produce analgesia. Using both agents has been proven to have a synergistic effect: The combined effect of these two medications is greater than the effect of the two medications administered alone (i.e. 1 + 1 = greater than 2).
Beaudoin FL. Combination of ibuprofen and acetaminophen is no different than low-dose opioid analgesic preparations in relieving short-term acute extremity pain. BMJ Evid Based Med. 2018;23(5):197-198.
Derry CJ, Derry S, Moore RA. Single dose oral ibuprofen plus paracetamol (acetaminophen) for acute postoperative pain. Cochrane Database Syst Rev. 2013;24(6)